Nicholas J Alp Selected Research

sapropterin (tetrahydrobiopterin)

10/2011	Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure.
5/2010	Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.
9/2008	CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.
7/2008	GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function.
5/2008	Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy.
7/2007	Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease.
4/2005	Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension.
3/2004	Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.
3/2004	Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.

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Nicholas J Alp Research Topics

Disease

7	Vascular Diseases (Vascular Disease) 05/2010 - 09/2003
6	Atherosclerosis 05/2010 - 03/2004
2	ST Elevation Myocardial Infarction 08/2014 - 04/2008
2	Fibrosis (Cirrhosis) 10/2011 - 05/2008
2	Hypertrophy 10/2011 - 05/2008
2	Phenylketonurias (Phenylketonuria) 01/2009 - 07/2004
2	Atherosclerotic Plaque (Atheroma) 01/2009 - 03/2004
2	Vascular System Injuries 09/2008 - 04/2007
2	Hyperplasia 04/2007 - 10/2002
2	Diabetes Mellitus 09/2004 - 09/2003
1	Bradycardia 03/2015
1	Neointima 11/2013
1	Heart Failure 10/2011
1	Heart Diseases (Heart Disease) 10/2011
1	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 10/2011
1	Atrial Remodeling 09/2011
1	Atrioventricular Block 09/2011
1	Atrial Fibrillation 09/2011
1	Inflammation (Inflammations) 05/2010
1	Arteritis 01/2009
1	Coronary Artery Disease (Coronary Atherosclerosis) 07/2008
1	Cardiomegaly (Heart Hypertrophy) 05/2008
1	Hypertension (High Blood Pressure) 02/2008
1	Pathologic Constriction (Stenosis) 04/2007
1	Pulmonary Hypertension 04/2005
1	Hypoxia (Hypoxemia) 04/2005
1	Infections 12/2004
1	Dystonia (Limb Dystonia) 07/2004

Drug/Important Bio-Agent (IBA)

9	sapropterin (tetrahydrobiopterin)FDA Link 10/2011 - 03/2004
6	Nitric Oxide (Nitrogen Monoxide)FDA Link 09/2011 - 03/2004
6	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2011 - 09/2003
6	GTP Cyclohydrolase (GTP Cyclohydrolase I)IBA 05/2010 - 03/2004
5	Apolipoproteins E (ApoE)IBA 11/2013 - 03/2004
5	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 05/2010 - 03/2004
4	Nitric Oxide Synthase (NO Synthase)IBA 10/2011 - 09/2004
4	Superoxides (Superoxide)IBA 01/2009 - 10/2005
3	EnzymesIBA 01/2009 - 03/2004
2	ArginaseIBA 09/2011 - 04/2008
2	AntioxidantsIBA 05/2008 - 07/2007
1	Levodopa (L Dopa)FDA LinkGeneric 03/2015
1	Endothelins (Endothelin)IBA 08/2014
1	Paclitaxel (Taxol)FDA LinkGeneric 11/2013
1	MetalsIBA 11/2013
1	Oxidoreductases (Dehydrogenase)IBA 09/2011
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 09/2011
1	LipidsIBA 05/2010
1	Pharmaceutical PreparationsIBA 05/2010
1	ApolipoproteinsIBA 05/2010
1	2-hydroxyethidiumIBA 01/2009
1	Doxycycline (Periostat)FDA LinkGeneric 01/2009
1	arginine methyl esterIBA 01/2009
1	Interleukin-1 (Interleukin 1)IBA 01/2009
1	CytokinesIBA 01/2009
1	BiopterinsIBA 07/2008
1	tempolIBA 05/2008
1	Oxidants (Oxidizing Agents)IBA 05/2008
1	CholesterolIBA 04/2008
1	Desoxycorticosterone Acetate (DOCA)FDA Link 02/2008
1	SodiumIBA 02/2008
1	SaltsIBA 02/2008
1	ReninIBA 02/2008
1	Acetates (Acetic Acid Esters)FDA Link 02/2008
1	Desoxycorticosterone (Deoxycorticosterone)IBA 02/2008
1	Green Fluorescent ProteinsIBA 12/2004
1	Proteins (Proteins, Gene)FDA Link 12/2004
1	Dihydroxyphenylalanine (Dopa)IBA 07/2004

Therapy/Procedure

3	Stents 11/2013 - 10/2002
2	Therapeutics 04/2008 - 04/2008
1	Drug-Eluting Stents 11/2013